Relative Potency of Commercial Secretins

Relative potency of commercial calibrators for fructosamine, and their effect on measurements of fructosamine in serum.

The protein-based secondary standardsfor serum fructosamine in a commercial test kit (Roche Diagnostics) have recently been modified by the manufacturer. Under certain assay conditions, the new calibrator gave significantly greater serum fructosamine values than those obtained with the originally supplied calibrator. However, for 20-4, samples and absorbance measurements at 10 and 15 mm, hereaf...

Relative Properties and Relative Potency of Various Hydrazide Compounds That Inhibit Growth of Mycobacterium tuberculosis

The molecular properties of compounds expressing growth inhibition of Mycobacterium tuberculosis are determined and examined for underlying relationships by pattern recognition methods. Pattern recognition methods such as hierarchical cluster analysis will show relationships between compounds. Descriptive statistical analysis of molecular properties reveal commonality among bacteriostatic compo...

Relative Potency Estimation in Direct Bioassay with Measurement Errors*

Estimating Relative Potency Based on Multivariate Risk/Benefit Assessment

Relative potency plays a key role in understanding the relationship between the doses of two treatments. Defined as the ratio of equally effective doses, it is central to communicating the relationship between a new drug entering the market and older medications. Because doses are tested and collected at discrete points in clinical trials, estimation in direct assays is hampered by the fact tha...

Fragrances Categorized According to Relative Human Skin Sensitization Potency

BACKGROUND The development of non-animal alternatives for skin sensitization potency prediction is dependent upon the availability of a sufficient dataset whose human potency is well characterized. Previously, establishment of basic categorization criteria for 6 defined potency categories, allowed 131 substances to be allocated into them entirely on the basis of human information. OBJECTIVES ...